Epithelial stem cells in the lining of the digestive tract occur in deep crypts and give rise to several cell types: Accessed December 22, The involved target tissue demonstrates a lymphocytic infiltration, even when the patient is lymphopenic from immunosuppression. As this study was a clinical trial, we were unable to label the cells so as to ascertain the extent to which they trafficked to the heart.
Response of patients to steroids as primary therapy for acute graft-versus-host disease: Patients with clinically significant primary valvular heart disease or evidence of life-threatening arrhythmia on baseline electrocardiogram ECG were also excluded. The following are examples of differentiation pathways of adult stem cells Figure 2 that have been demonstrated in vitro or in vivo.
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Finally, they represent an enriched population of cells with therapeutic properties, as demonstrated in pre-clinical studies 8. The ability of a differentiated stem cell of one lineage to produce cells of a different lineage is called transdifferentiation. Left ventricular volumes were determined at end-diastole and -systole. By using this site, you agree to the Terms of Use and Privacy Policy.
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Schulman , Gary Gerstenblith , Anthony N. Over the follow-up period, evidence of prevention of wall thinning and reduction in percentage of wall motion abnormalities was observed in hMSC-treated patients data not shown. Day ] Secondary Outcome Measures: The primary end point was incidence of treatment-emergent adverse events within 6 months. Thus, a source of cells can be generated that are specific to the donor, thereby increasing the chance of compatibility if such cells were to be used for tissue regeneration.
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