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Adult Human Mesenchymal

Epithelial stem cells in the lining of the digestive tract occur in deep crypts and give rise to several cell types: Accessed December 22, The involved target tissue demonstrates a lymphocytic infiltration, even when the patient is lymphopenic from immunosuppression. As this study was a clinical trial, we were unable to label the cells so as to ascertain the extent to which they trafficked to the heart.

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Response of patients to steroids as primary therapy for acute graft-versus-host disease: Patients with clinically significant primary valvular heart disease or evidence of life-threatening arrhythmia on baseline electrocardiogram ECG were also excluded. The following are examples of differentiation pathways of adult stem cells Figure 2 that have been demonstrated in vitro or in vivo.




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Finally, they represent an enriched population of cells with therapeutic properties, as demonstrated in pre-clinical studies 8. The ability of a differentiated stem cell of one lineage to produce cells of a different lineage is called transdifferentiation. Left ventricular volumes were determined at end-diastole and -systole. By using this site, you agree to the Terms of Use and Privacy Policy.


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Schulman , Gary Gerstenblith , Anthony N. Over the follow-up period, evidence of prevention of wall thinning and reduction in percentage of wall motion abnormalities was observed in hMSC-treated patients data not shown. Day  ] Secondary Outcome Measures: The primary end point was incidence of treatment-emergent adverse events within 6 months. Thus, a source of cells can be generated that are specific to the donor, thereby increasing the chance of compatibility if such cells were to be used for tissue regeneration.


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